Objective: It was observed with patients who received zoledronic acid that there were complaints of increase in pain and fever therefore to know the intensity of both, this project was initiated to measure grade of pain and fever with zoledronic acid and to identify the preventive measures taken to counter the effects caused by zoledronic acid.
Method: We collected data of a total of 72 patients who were electively admitted at daycare oncology, The Aga Khan University Hospital, Karachi from 4th of April, 2019 till 12th of July, 2019. A questionnaire form was prepared by a multidisciplinary team of medical oncologist, daycare nursing staff and Staff medical officer. A consensus was made to identify the following mentioned side effects.
1. Pain 
2. Fever 
Result: Out of 72 patients it was seen that after getting injection of Zoledronic acid only 21 patients reported with low grade fever whereas the rest of them were symptomless and 15 patients out of 72 went through mild pain either in the body or some specific part such as legs or arms, 02 of them experienced moderate pain and 02 had severe pain, while 53 patients went through no symptom at all.
Conclusion: Most of the patients had mild pain and low grade fever. These symptoms were adequately managed with paracetamol tablet.