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International Journal of Oncology Sciences

Vol. 1, Issue 1, Part A (2019)

Molecular detection of john cunningham virus (JCV) in patients with colorectal cancer in khartoum, Sudan

Author(s):

Eman I Mohamed, Abdel Rahim M El Hussein, Isam M Elkhidir, Khalid A Enan

Abstract:

Background: Colorectal cancer (CRC) is the most repetitious malignancies with high mortality worldwide. JC virus (JCV) is ubiquitous Polyomavirus, with seroprevalence rates ranging from 70% to 90% in adult population. Recently the roles of JCV have been reported in many malignant tumors worldwide. The association of JCV was reported in patients with colon and rectum cancers Objective: the study was conducted to evaluate the association of JCV DNA in patients with colorectal cancer in Khartoum State. Materials and methods: A total of 70 formalin-fixed paraffin-embedded tissue block samples were collected including 33 (47.1%) male 37 (52.9%) female patients with CRC. DNA was extracted from all the samples. Nested PCR was carried out for detection of Vp1/T Ag junction genome in JCV genome by Nested-PCR assay. Results: 3/70(4.2%) samples of patients were positive for JCV DNA (P 0.522). Out of 3 samples positive for JC DNA, 2(2.8%) were males and 1(1.4%) was female. Conclusion: prevalence of JCV DNA was 4.2% among patients with CRC. Including 2.8% male and 1.4% female (p= 0.522). The subsequent T-Ag protein expression might explain the increased risk of colorectal cancer and requires further investigation

Pages: 01-03  |  1627 Views  706 Downloads


International Journal of Oncology Sciences
How to cite this article:
Eman I Mohamed, Abdel Rahim M El Hussein, Isam M Elkhidir, Khalid A Enan. Molecular detection of john cunningham virus (JCV) in patients with colorectal cancer in khartoum, Sudan. Int. J. Oncol. Sci. 2019;1(1):01-03. DOI: 10.33545/26649322.2019.v1.i1a.1
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International Journal of Oncology Sciences

International Journal of Oncology Sciences