As tumors grow, develop, angiogenesis, progress and metastasis, the tumor microenvironment (TME) changes or evolves. Targeting TME is a substantial matter in tumor biology. Targeting TME through multi-dimensional ways should be accepted to treat the cancers. Understanding how the tumor microenvironment treated by multiple ways are considered in this mini review. this could aid in the development of effective therapeutics to target cancer cell invasion and metastasis.